Schilling Lab Publications

  • Zou W, Rohatgi N, Chen TH, Schilling J, Abu-Amer Y, Teitelbaum SL.  PPARg regulates pharmacological but not physiological or pathologic osteoclast formation. Nat Med. 2016 Nov 8;22(11):1203-1205
  • He L, Weber KJ, Diwan A, and Schilling JD. Inhibition of mTOR reduces lipotoxic cell death in primary macrophages through an autophagy-independent mechanism. J Leuk Biol. 2016 Nov; 100(5): 1113-1124. PMCID: 27312848
  • Huang SC, Smith AM, Everts B, Colonna M, Pearce EL, Schilling JD, Pearce EJ. Metabolic Reprogramming Mediated by the mTORC2-IRF4 Signaling Axis is Essential for Macrophage Alternative Activation.  Immunity. 2016 Oct 18;45(4):817-830. PMCID: 27760338
  • Artyomov MN, Sergushichev A, Schilling JD. Integrating immunometabolism and macrophage diversity. Semin Immunol. 2016 Oct 19 pil:S1044-5323 (16) 30105-1 PMCID: 27771140
  • Schilling JD.  Dousing fire with gasoline: interplay between lysosome damage and the NLRP3 inflammasome. Am J Physiol Cell Physiol. 2016. Jun;  PMCID: 27306368
  • He L, Weber KJ, and Schilling JD.  Glutamine Modulates Macrophage Lipotoxicity. Nutrients.2016. Apr;12 (4). PCMID: 27077881
  • Schilling JD. The Mitochondria in Diabetic Heart Failure: from pathogenesis to therapeutic promise. Antioxid Redox Signal. 2015. PCMID: 25761843
  • Larue SJ, Garcia-Cortes R, Nassif M, Vader J, Shuddhadeb R, Ravichandran A, Rasalingham R, Silvestry S, Ewald G, Wang I, and Schilling JD. Treatment of Secondary Pulmonary Hypertension with Bosentan After Left Ventricular Assist Device Implantation. Cardiovasc Ther. 2015. Apr;33(2):50-5. PMCID: 25759010
  • Symington JW, Wang C, Twentyman J, Owusu-Boaitey N, Schwendener R, Nunez G, Schilling JD, and Mysorekar IU. ATG16L1 deficiency in macrophages drives clearance of uropathogenic E. coli in an IL-1b- dependent manner. Mucosal Immunol. 2015. Feb 11. PMCID: 25669147
  • Schilling JD and Mann DL. Diabetic Cardiomyopathy: Distinct and Preventable Entity or Inevitable Consequence. Curr Cardiovasc Risk Rep. 2014 8:417. PCMID: Pending
  • Weber K and Schilling J. Distinct Lysosome Phenotypes Influence Inflammatory Function in Peritoneal and Bone Marrow-Derived Macrophages. Int J Inflam. 2014 154936. PMCID: 25587484
  • Lavine KJ, Epelman S, Uchida K, Weber KJ, Nichols CG, Schilling JD, Ornitz DM, Randolph GJ, Mann DL. Distinct Macrophage Lineages Contribute to Disparate Patterns of Cardiac Recovery and Remodeling in the Neonatal and Adult Heart. PNAS. 2014. Nov. 11;111(45):16029-34. PMCID 25349429
  • Rajan A, Adam L, Scott M, and Schilling J. Elevated Troponin in Association with Autoimmune Cardiomyopathy: always a marker of cardiac damage? Exp Clin Cardiol. 2014. 20(8):3741-3744.
  • Weber K and Schilling JD. The Lysosome Mediates Metabolic-Inflammatory Crosstalk in Primary Macrophages. J. Biol Chem. 2014. March 28; 289(13):9158-71. PMCID: 24532802
  • Epelman S, Lavine KJ, Beaudin AE, Sojka DK, Carrero JA, Calderon B, Brija T, Gautier EL, Ivanov S, Satpathy AT, Schilling JD, Schwendener R, Sergin I, Razani B, Forsberg EC, Yokoyama WM, Unanue ER, Colonna M, Randolph GJ, Mann DL. Embryonic and Adult-Derived Resident Cardiac Macrophages are Maintained through Distinct Mechanisms at Steady State and during Inflammation. Immunity. 2014. Jan 16; 40(1):91-104. PMICD: 24439267
  • Ravichandran AK, Parker J, Novak E, Joseph S, Schilling J, Ewald G, and Silvestry S. Hemolysis in Left Ventricular Assist Device: A retrospective analysis of outcomes. J Heart Lung Transplant. 2014. Jan; 33(1):44-50. PCMID: 24418733
  • Ravichandran AK, Schilling J, Pfeifer J, Ewald G, and Joseph S. Rituximab is Associated with Improved Survival in Cardiac Allograft Patients with Antibody Mediated Rejection: A Single Center Review. Clin Transplant. 2013. Nov; 27(6): 961-7. PCMID: 24304378
  • Schilling JD, Machkovech H, He L, Sidhu R, Fujiwara H, Weber K, Ory DS, and Schaffer, JE. Palmitate and LPS trigger Synergistic Ceramide Production in Primary Macrophages. J Biol Chem. 2013. Feb 1;288(5):2923-32. PCMID: 23250746
  • Schilling JD, Machkovech H, He L, Diwan A, Schaffer JE. TLR4 Activation Under Lipotoxic Conditions Leads to Synergistic Macrophage Cell Death Through a TRIF-Dependent Pathway. J Immunol. 2013. Feb;190(3). PCMID: 23275600
  • Lindley KJ, Ravichandran AK, Schilling JD, Joseph SM. MD Antibody Mediated Rejection of the Heart in the Setting of Autoimmune Demyelinating Polyneuropathy: A Case Report and Review of the Literature. Case Reports in Cardiology. Case Reports in Cardiology, vol. 2012, Article ID 639284, 4 pages, 2012. doi:10.1155/2012/639284
  • Schilling JD, Machkovech H, Kim A, Schwendener, R, and Schaffer JE. Macrophages Modulate Cardiac Function in Lipotoxic Cardiomyopathy. Am J Physiolo Heart Circ Physiol. 2012. Dec;303(11):H1366-73. PCMID: 23042950.
  • Schilling JD and Mann DL. Diabetic Cardiomyopathy: Bench to Bedside. Heart Fail Clin. 2012. Oct;8(4):619-31. PMCID:22999244
  • Schilling JD and Kelly DP. The PGC-1 Cascade as a Therapeutic Target for Heart Failure. J Mol Cell Cardiol. 2011, 51(4): 578-83. PMCID: PMC3042046.
  • Razani B, Zhang H, Schulze PC, Schilling JD, Verbsky J, Lodhi IJ, Topkara VK, Feng C, Coleman T, Kovacs A, Kelly DP, Saffitz JE, Dorn GW, Nichols CG, and Semenkovich CF. Fatty acid synthase modulates homeostatic response to myocardial stress. J Biol Chem. 2011. 286(35): 30949-61. PMCID: PMC3162454.
  • Schilling JD, Lai L, Sambandam, N, Dey C, Leone TL, and Kelly DP. Toll-like Receptor-Mediated Inflammatory Signaling Reprograms Cardiac Energy Metabolism by Repressing Peroxisome Proliferator-activated receptor g Coactivator-1 (PGC-1) Signaling. Circ Heart Fail. 2011. 4(4): 474-482. PMCID: PMC3144030.