Publications

Schilling Lab Publications

• Chan M.M., He L., Finck B.N., Schilling J.D., Daemen S. (2024) Hepatic stellate cells drive differentiation of monocyte-derived macrophages to regulate liver fibrosis in MASH. Journal of Immunology. doi.org/10.4049/jimmunol.2300847
• Han J., Gallerand A., Erlich E.C., Helmink B.A., Mair I., Li X., Eckhouse S.R., Dimou F.M., Shakhsheer B.A., Phelps H., Chan M.M., Schilling J.D., Finlay C.M., Allen J.E., Jakubzick C.V., Else K., Onufer E.J., Zhang N., Randolph G.J. Human serous cavity macrophages and dendritic cells possess counterparts in the mouse with a distinct distribution between species. Nature Immunology. 2023 Dec; PMID: 38102487
• Chan M.M., Daemen S., Beals J.W., Terekhova M., Yang B.Q., Fu C.F., He L., Park A.C., Smith G.I., Razani B., Brynes K., Beatty W.L., Eckhouse S.R., Egon J.C., Ferguson D., Finck B.N., Klein S., Artyomov M.N., Schilling J.D. Steatosis Drives Monocyte-derived Macrophage Accumulation in Human Metabolic Dysfunction-Associated Fatty Liver Disease. Journal of Hepatology Reports. 2023 Aug; PMID: 37869071
• Yang BQ, Park AC, Liu J, Byrnes K, Javaheri A, Mann DL, Schilling JD. Distinct Inflammatory Milieu in Patients With Right Heart Failure. Circ Heart Fail. 2023 Aug;16(8):e010478. PMID: 37395128
• Zhang X, Evans TD, Chen S, Sergin I, Stitham J, Jeong SJ, Rodriguez-Velez A, Yeh YS, Park A, Jung IH, Diwan A, Schilling JD, Rom O, Yurdagul A, Epelman S, Cho J, Lodhi IJ, Mittendorfer B, Razani B. Loss of Macrophage mTORC2 Drives Atherosclerosis via FoxO1 and IL-1β Signaling. Circ Res. 2023 Jul 21;133(3):200-219. PMID: 37350264
• Yang BQ, Park AC, Liu J, Byrnes K, Javaheri A, Mann DL, Schilling JD. A Distinct Inflammatory Milieu in Patients with Right Heart Failure. medRxiv. 2023 Apr 17;2023.04.12.23288502. PMID: 37131722
• Susheel K. Gunasekar, John Heebink, Danielle H. Carpenter, Ashutosh Kumar, Litao Xie, Haixia Zhang, Joel D. Schilling, Rajan Sah. Adipose-targeted SWELL1 deletion exacerbates obesity- And age-related nonalcoholic fatty liver disease. JCI Insight. 2023 Mar 8;8(5):e154940. PMID: 36749637
• Borcherding N.*, Jia W.*, Giwa R., Field R.L., Moley J.R.,  Kopecky B.J., Chan M.M., Yang B.Q., Sabio J.M.; Walker E.C., Osorio O., Bredemeyer A., Pietka T., Alexander-Brett J., Morley S.C.,  Artyomov M.N., Abumrad N.A.,  Schilling J.D., Lavine K., Crewe C., Brestoff J.R. Dietary lipids inhibit mitochondria transfer to macrophages to divert adipocyte-derived mitochondria into the blood. Cell Metabolism. 2022 Oct; PMID: 36070756 *Authors contribute equally
• Jonathan D. Moreno, Amanda K. Verma, Benjamin J. Kopecky, Carina Dehner, Nicolas Kostelecky, Justin M. Vader, Chieh Yu Lin, Joel Schilling. Angiotensin II Type 1 Receptor Antibody-mediated Rejection Following Orthotopic Heart Transplant: A Single-center Experience. Transplantation. 2022 Feb 1;106(2):373-380. PMID: 33988339
• Michael J. Finnan, Nadia H. Bakir, Akinobu Itoh, Kunal D. Kotkar, Michael K. Pasque, Ralph J. Damiano, Marc R. Moon, Gregory A. Ewald, Joel D. Schilling, Muhammad F. Masood. 30 Years of Heart Transplant: Outcomes After Mechanical Circulatory Support From a Single Center. Ann Thorac Surg. 2022 Jan;113(1):41-48. PMID: 33675715
• Nadia H. Bakir, Michael J. Finnan, Robert M. MacGregor, Joel D. Schilling, Gregory A. Ewald, Kunal D. Kotkar, Akinobu Itoh, Ralph J. Damiano, Marc R. Moon, Muhammad F. Masood. Cardiac allograft rejection in the current era of continuous flow left ventricular assist devices. J Thorac Cardiovasc Surg. 2022 Jan;163(1):124-134.e8. PMID: 33012541
• Nadia H. Bakir, Michael J. Finnan, Akinobu Itoh, Michael K. Pasque, Gregory A. Ewald, Kunal D. Kotkar, Ralph J. Damiano, Marc Moon, Justin C. Hartupee, Joel Schilling, Muhammad F. Masood. Competing Risks to Transplant in Bridging With Continuous-flow Left Ventricular Assist Devices. Ann Thorac Surg. 2021 Nov 19;S0003-4975(21)01973-1. PMID: 34808111

• Sabine Daemen, Mandy M. Chan, Joel D. Schilling. Comprehensive analysis of liver macrophage composition by flow cytometry and immunofluorescence in murine NASH. STAR Protoc. 2021 Apr 29;2(2):100511. PMID: 33997821

• Schilling JD. Macrophages Fuel Skeletal Muscle Regeneration. Immunometabolism. 2021;3(2):e210013. https://doi.org/10.20900/immunometab20210013
• Daemen S, Gainullina A, Kalugotla G, He L, Chan MM, Beals JW, Liss KH, Klein S, Feldstein AE, Finck BN, Artyomov MN, Schilling JD. Dynamic Shifts in the Composition of Resident and Recruited Macrophages Influence Tissue Remodeling in NASH. Cell Rep. 2021 Jan 12;34(2):108626. PMID: 33440159
• Liu J, Yang BQ, Itoh A, Masood MF, Hartupee JC, Schilling JD. Impact of New UNOS Allocation Criteria on Heart Transplant Practices and Outcomes. Transplant Direct. 2020 Dec 15;7(1):e642. PMID: 33335981
• King PM, Raymer DS, Shuster J, Crain M, Bhatia A, Hartupee J, Schilling JD. Right Heart Failure While on Left Ventricular Assist Device Support Is Associated with Primary Graft Dysfunction. ASAIO J. 2020 Nov/Dec;66(10):1137-1141. PMID: 33136601
• Schilling JD. Trimming the Fat in HFpEF: Learning How to Target the Metabolic Disease Phenotype. JACC Basic Transl Sci. 2020 Sep 28; 5(9):928-930. PMCID: PMC 33016957
• Chu AL, Schilling JD, King KR, and Feldstein AE. The Power of Single Cell Analysis for the Study of Liver Pathobiology.  Hepatology, 2020 Aug 1. PMID: 32740968
• Chandra P, He L, Zimmerman M, Yang G, Köster S, Ouimet M, Wang H, Moore KJ, Dartois V, Schilling JD, Philips JA. Inhibition of Fatty Acid Oxidation Promotes Macrophage Control of Mycobacterium tuberculosis. mBio. 2020 Jul 7;11(4):e01139-20. PMID: 32636249
•   Daemen S and Schilling JD. The interplay between tissue niche and macrophage cellular metabolism in obesity.  Front Immunol, 2020 January 22. PMID:32038642
• Zhang X, Sergin I, Evans TD, Jeong S, Rodrigues-Velez A, Kapoor D, Chen S, Song E, Holloway KB, Crowley JR, Epelman S, Weihl CC, Diwan A, Fan D, Mittendorfer B, Stiziel NA, Schilling JD, Lodhi IJ, and Razani B. High-protein Diets Increase Cardiovascular Risk by Activating Macrophage mTOR to Suppress Mitophagy. Nat. Metab. 2020 Jan; 2(1) PMCID: PMC 32128508
• Javiheri A, Bajpai G, Picataggi A, Mani S, Foroughi L, Evie H, Kovacs A, Weinhemier CJ, Hyrc K, Xiao Q, Ballabio A, Lee JM, Matkovich SJ, Razani B, Schilling JD, Lavine KJ, and Diwan A. TFEB activation in macrophages attenuates postmyocardial infraction ventricular dysfunction independently of ATG5-mediate autophagy. JCI insight. 2019 Nov 1;4(21) PMCID: PMC31672943
• Kalugotla G, He L, Weber KJ, Daemen S, Reller A, Razani B, and Schilling JD. Frontline Science: Acyl-CoA synthetase 1 exacerbates lipotoxic inflammasome activation in primary macrophages. J Leukoc Biol. 2019. Oct 5 PMCID: PMC31166619
• Weber KJ, Sauer M, He L, Tycksen E, Kalugotla G, Razani B, and Schilling JD.  PPARg Deficiency Suppresses the Release of IL-1b and IL-1a in Macrophages via a Type 1 Interferon Dependent Mechanism.  J Immunol, 2018. 201(7):2054-2069. PMCID: PMC30143592.
• Adamo L, Staloch LJ, Rocha-Resende C, Matkovich SJ, Jiang W, Bajpai G, Weinheimer CJ, Kovacs A, Schilling JD, Barger PM, Bhattacharya D, Mann DL. Modulation of subsets of cardiac B lymphocytes improve cardiac function after acute injury. JCI Insight, 2018. 3(11): pii: 120137. doi: 10.1172/jci.insight.120137. PMCID: PMC6124442.
• Zhang Y, Rotagi N, Veis DJ, Schilling J, Teitelbaum SL, Zou W.  PGC1b Organizes the Osteoclast Cytoskeleton by Mitochondrial Biogenesis and Activation.  J Bone Miner Res, 2018. 33(6):1114-1125. PMCID: PMC6002881.
• Sparrow CT, Larue SJ, Schilling JD.  Intersection of Pulmonary Hypertension and Right Ventricular Dysfunction in Patients on Left Ventricular Assist Device Support: Is There a Role for Pulmonary Vasodilators?  Circ Heart Fail, 2018. 11(1): e004255. doi: 10.1161/CIRCHEARTFAILURE.117.004255.  PMID: 29321132.
• Ravichandran AK, Larue SJ, Novak E, Joseph SA, Schilling JD. Sildenafil in Left Ventricular Assist Devices is Safe and Well-Tolerated. ASAIO J, 2018. 64(2):280-281. PMID: 28692527.
• Sergin I, Evans, TD, Zhang X, Bhattacharya S, Stokes CJ, Song E, Ali S, Dehestani B, Holloway KB, Micevych PS, Javaheri A, Crowley JR, Ballabio A, Schilling JD, Epelman S, Weihl CC, Diwan A, Fan D, Zayed MA, Razani B.  Exploiting macrophage autophagy-lysosomal biogenesis as a therapy for atherosclerosis. Nat. Commun, 2017. 8:15750. PMCID: PMC5467270.
• Zou W, Rohatgi N, Chen TH, Schilling J, Abu-Amer Y, Teitelbaum SL.  PPARg regulates pharmacological but not physiological or pathologic osteoclast formation. Nat Med. 2016 Nov 8;22(11):1203-1205
• He L, Weber KJ, Diwan A, and Schilling JD. Inhibition of mTOR reduces lipotoxic cell death in primary macrophages through an autophagy-independent mechanism. J Leuk Biol. 2016 Nov; 100(5): 1113-1124. PMCID: 27312848
• Huang SC, Smith AM, Everts B, Colonna M, Pearce EL, Schilling JD, Pearce EJ. Metabolic Reprogramming Mediated by the mTORC2-IRF4 Signaling Axis is Essential for Macrophage Alternative Activation.  Immunity. 2016 Oct 18;45(4):817-830. PMCID: 27760338
• Artyomov MN, Sergushichev A, Schilling JD. Integrating immunometabolism and macrophage diversity. Semin Immunol. 2016 Oct 19 pil:S1044-5323 (16) 30105-1 PMCID: 27771140
• Schilling JD.  Dousing fire with gasoline: interplay between lysosome damage and the NLRP3 inflammasome. Am J Physiol Cell Physiol. 2016. Jun;  PMCID: 27306368
• He L, Weber KJ, and Schilling JD.  Glutamine Modulates Macrophage Lipotoxicity. Nutrients. 2016. Apr;12 (4). PCMID: 27077881
• Schilling JD. The Mitochondria in Diabetic Heart Failure: from pathogenesis to therapeutic promise. Antioxid Redox Signal. 2015. PCMID: 25761843
• Larue SJ, Garcia-Cortes R, Nassif M, Vader J, Shuddhadeb R, Ravichandran A, Rasalingham R, Silvestry S, Ewald G, Wang I, and Schilling JD. Treatment of Secondary Pulmonary Hypertension with Bosentan After Left Ventricular Assist Device Implantation. Cardiovasc Ther. 2015. Apr;33(2):50-5. PMCID: 25759010
• Symington JW, Wang C, Twentyman J, Owusu-Boaitey N, Schwendener R, Nunez G, Schilling JD, and Mysorekar IU. ATG16L1 deficiency in macrophages drives clearance of uropathogenic E. coli in an IL-1b- dependent manner. Mucosal Immunol. 2015. Feb 11. PMCID: 25669147
• Schilling JD and Mann DL. Diabetic Cardiomyopathy: Distinct and Preventable Entity or Inevitable Consequence. Curr Cardiovasc Risk Rep. 2014 8:417. PCMID: Pending
• Weber K and Schilling J. Distinct Lysosome Phenotypes Influence Inflammatory Function in Peritoneal and Bone Marrow-Derived Macrophages. Int J Inflam. 2014 154936. PMCID: 25587484
• Lavine KJ, Epelman S, Uchida K, Weber KJ, Nichols CG, Schilling JD, Ornitz DM, Randolph GJ, Mann DL. Distinct Macrophage Lineages Contribute to Disparate Patterns of Cardiac Recovery and Remodeling in the Neonatal and Adult Heart. PNAS. 2014. Nov. 11;111(45):16029-34. PMCID 25349429
• Rajan A, Adam L, Scott M, and Schilling J. Elevated Troponin in Association with Autoimmune Cardiomyopathy: always a marker of cardiac damage? Exp Clin Cardiol. 2014. 20(8):3741-3744.
• Weber K and Schilling JD. The Lysosome Mediates Metabolic-Inflammatory Crosstalk in Primary Macrophages. J. Biol Chem. 2014. March 28; 289(13):9158-71. PMCID: 24532802
• Epelman S, Lavine KJ, Beaudin AE, Sojka DK, Carrero JA, Calderon B, Brija T, Gautier EL, Ivanov S, Satpathy AT, Schilling JD, Schwendener R, Sergin I, Razani B, Forsberg EC, Yokoyama WM, Unanue ER, Colonna M, Randolph GJ, Mann DL. Embryonic and Adult-Derived Resident Cardiac Macrophages are Maintained through Distinct Mechanisms at Steady State and during Inflammation. Immunity. 2014. Jan 16; 40(1):91-104. PMICD: 24439267
• Ravichandran AK, Parker J, Novak E, Joseph S, Schilling J, Ewald G, and Silvestry S. Hemolysis in Left Ventricular Assist Device: A retrospective analysis of outcomes. J Heart Lung Transplant. 2014. Jan; 33(1):44-50. PCMID: 24418733
• Ravichandran AK, Schilling J, Pfeifer J, Ewald G, and Joseph S. Rituximab is Associated with Improved Survival in Cardiac Allograft Patients with Antibody Mediated Rejection: A Single Center Review. Clin Transplant. 2013. Nov; 27(6): 961-7. PCMID: 24304378
• Schilling JD, Machkovech H, He L, Sidhu R, Fujiwara H, Weber K, Ory DS, and Schaffer, JE. Palmitate and LPS trigger Synergistic Ceramide Production in Primary Macrophages. J Biol Chem. 2013. Feb 1;288(5):2923-32. PCMID: 23250746
• Schilling JD, Machkovech H, He L, Diwan A, Schaffer JE. TLR4 Activation Under Lipotoxic Conditions Leads to Synergistic Macrophage Cell Death Through a TRIF-Dependent Pathway. J Immunol. 2013. Feb;190(3). PCMID: 23275600
• Lindley KJ, Ravichandran AK, Schilling JD, Joseph SM. Antibody Mediated Rejection of the Heart in the Setting of Autoimmune Demyelinating Polyneuropathy: A Case Report and Review of the Literature. Case Reports in Cardiology, vol. 2012, Article ID 639284, 4 pages, 2012. doi:10.1155/2012/639284
• Schilling JD, Machkovech H, Kim A, Schwendener, R, and Schaffer JE. Macrophages Modulate Cardiac Function in Lipotoxic Cardiomyopathy. Am J Physiolo Heart Circ Physiol. 2012. Dec;303(11):H1366-73. PCMID: 23042950.
• Schilling JD and Mann DL. Diabetic Cardiomyopathy: Bench to Bedside. Heart Fail Clin. 2012. Oct;8(4):619-31. PMCID:22999244
• Schilling JD and Kelly DP. The PGC-1 Cascade as a Therapeutic Target for Heart Failure. J Mol Cell Cardiol. 2011, 51(4): 578-83. PMCID: PMC3042046.
• Razani B, Zhang H, Schulze PC, Schilling JD, Verbsky J, Lodhi IJ, Topkara VK, Feng C, Coleman T, Kovacs A, Kelly DP, Saffitz JE, Dorn GW, Nichols CG, and Semenkovich CF. Fatty acid synthase modulates homeostatic response to myocardial stress. J Biol Chem. 2011. 286(35): 30949-61. PMCID: PMC3162454.
• Schilling JD, Lai L, Sambandam, N, Dey C, Leone TL, and Kelly DP. Toll-like Receptor-Mediated Inflammatory Signaling Reprograms Cardiac Energy Metabolism by Repressing Peroxisome Proliferator-activated receptor g Coactivator-1 (PGC-1) Signaling. Circ Heart Fail. 2011. 4(4): 474-482. PMCID: PMC3144030.

View a complete list of Schilling lab publications